Beyond its role in development and neurological health, Shh also plays a important role to the occurrence and development of cancer, such as lung [26],prostate [27], breast [28], colon [29], ovarian [30], pancreatic [31], hepatocellular carcinoma [32], bladder [33] and renal cell carcinoma [34]. The gene discussed is SHH; the disease is hereditary clear cell renal cell carcinoma.