Dormoy et al. through two experimental methods, quantitative RT-PCR and immunoblotting, observed that in RCC, even in most cases, the von Hippel-Lindau (VHL) tumor suppressor gene was inactivated, but SHH signaling pathway remained activated [35]., this indicates the universality of the SHH signaling pathway in RCC. This evidence concerns the gene VHL and renal cell carcinoma.