In the ADPKD model mice, genetic manipulation of PKD2 gene re-expression restores polycystic kidneys, implying that the epithelial phenotypes of ADPKD, including the expanded lumen size and isolated cysts, are reversible and that polycystin complex activators are potential unique therapeutics for ADPKD (Dong et al, 2021). This evidence concerns the gene PKD2 and autosomal dominant polycystic kidney disease.