So far, we demonstrated i) the Foxp1‐HIF1ɑ‐Hand1 signaling pathway in CMs is important for the metabolic transition to glycolysis, cell proliferation, and heart regeneration, and ii) deletion of Foxp1 in CMs increased HIF1ɑ‐Hand1 expression, enhancing metabolic transition, and iii) induced expression of Foxp1 in CMs inhibits cell proliferation and heart regeneration, leading to cardiac dysfunction in post‐MI hearts. The gene discussed is HAND1; the disease is myocardial infarction.