AKT activation has been widely reported in HCC and served as an important means for the construction of mouse primary liver cancer models.[28] Activated AKT phosphorylates PCK1 and then activates SREBP2 for cholesterol synthesis.[29] Our findings further reveal cholesterol, upstream of AKT, regulates AKT phosphorylation to promote HCC progression. Here, SREBF2 is linked to liver cancer.