Most recently, EVs derived from head and neck squamous cell carcinoma were shown to induce a pro‐tumor phenotype of neutrophils via directly delivering the immunosuppressive molecules, such as PD‐L1 and CD73.[150]  The transformed neutrophils were shown to mediate Treg cell aggregation and T cell dysfunction via the CD73/ PD‐L1 pathway, which collectively allows tumor cells to evade immune surveillance.[150]. This evidence concerns the gene NT5E and neoplasm.