The phosphorylation of the CTD of POLR2A is also important for the coordination of transcription events.[41] Nevertheless, circMETTL6 overexpression sufficiently prevents GDF15 transcription in a POLR2A‐dependent manner, and GDF15 overexpression can counteract the inhibitory effects of circMETTL6 on ovarian cancer cell proliferation and metastasis. This evidence concerns the gene GDF15 and ovarian cancer.