METTL6, a tRNA methyltransferase, is known for catalyzing the formation of 3‐methylcytidine at C32 position of specific serine tRNA isoacceptors.[15, 16] While METTL6 is upregulated in hepatocellular carcinoma (HCC) and promotes tumor progression by affecting cell adhesion molecules,[17] we observed that METTL6 itself did not show differential expression in ovarian cancer. This evidence concerns the gene METTL6 and hepatocellular carcinoma.