With adequate choice of study design, confounding variables and causal estimator, the average treatment effect matches well published findings: Pooling evidence from high-quality RCTs, no effect of albumin in severe sepsis was demonstrated for both 28-day mortality (odds ratio (OR) 0.93, 95% CI 0.80-1.08) and 90-day mortality (OR 0.88, 95% CI 0.761.01) [80]. This evidence concerns the gene ALB and Sepsis.