Excessively expressed MYC leads to the accumulation of M2‐like macrophages from the bone marrow, which secretes TGFβ, to induce the expression of FOSL2 in tumor cells, thereby remodeling chromatin accessibility at promoter regions of MP‐pattern genes to promote the MYC‐mediated de novo transcriptional regulation of these genes. This evidence concerns the gene FOSL2 and neoplasm.