VANGL2 and inflammatory bowel disease: To determine the role of VANGL2 in IBD and whether key innate immune pathways are involved, we generated myeloid conditional knockout of Vangl2 (Vangl2ΔM/ΔM) by breeding Vangl2flox/flox mice with Lyz2-Cre mice (S1C Fig), and the knockout efficiency of VANGL2 protein in myeloid cells was verified by immunoblot analysis (S1D Fig).