CD4 and Menkes disease: MD pathogenesis involves three main stages: an early cytolytic phase (2–7 dpi) mainly targeting and infecting B lymphocytes [64,65], activating CD4+ T cells; a latent phase with no viral antigen expression; and a second cytolytic phase leading to rapid proliferation of latently infected and transformed lymphocytes, resulting in tumor formation in tissues [5,66,67].