They extended these studies to show that three different murine HHT models (Smad4iECKO, Alk1iECKO, EngiECKO) all featured increased Angpt2 expression and concomitant downregulation of Tie2, as well as a transcriptional signature of increased angiogenesis and cell migration. Here, ANGPT2 is linked to hereditary hemorrhagic telangiectasia.