INS and obesity due to melanocortin 4 receptor deficiency: Other non-randomized studies showed a slight reduction in fasting glucose or Hb1Ac [262, 263], however most of the randomized controlled studies in patients with obesity but without type 2 diabetes agree that TRE do not have a significant impact on glycemic control or insulin sensitivity [188, 236, 239–243, 245, 249–253].