In a randomized controlled crossover trial, 11 men with obesity followed a 8-h TRE protocol and at the 5th day underwent a 24-h laboratory assessment: area under the curve for venous glucose tended to be lower for TRE compared to controls [188], suggesting a potential role for TRE in restoring insulin-sensitivity. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.