In models of abdominal aortic aneurysm (AAA), HHcy exacerbates Angiotensin II (Ang II)-induced aneurysm formation and increases immune cell infiltration, along with elevated production of cytokines such as interleukin-6 (IL-6) and C-C motif chemokine ligand 2. The gene discussed is AGT; the disease is abdominal aortic aneurysm.