HERPUD1 and Alzheimer disease: The same study also found that Herpud1 knockout decreased amyloid-β40 (Aβ40) expression, which is implicated in both Alzheimer’s disease and atherosclerosis, and improved endothelial function by promoting proliferation and reducing apoptosis, suggesting that Herpud1 represents a therapeutic target in Hcy-induced atherosclerosis [160].