CD40LG and malaria: As early as 1980, the World Health Organization's “Garki Project” (a malaria epidemiological study in West Africa) found that the malaria prevalence rate in males was higher than in females, with lower levels of anti‐malarial parasite antibodies (IHA, IgM) in serum, and this difference was most pronounced in the age groups of 9–18 and 19–28 [66].