In this regard, it may be valuable to consider that human disorders associated with mutations in ZC3H14, which cause a form of intellectual disability [24], and in PABPN1, with give rise to oculopharyngeal muscular dystrophy [64], may be linked to the disruption of this dynamic interplay between nuclear PABPs. Here, ZC3H14 is linked to oculopharyngeal muscular dystrophy.