One way to regulate oncogenic and tumor-suppressing signaling pathways is by modulating the sensitivity of cells to mitochondrial-dependent apoptosis through the convergence of the Bcl-2 family of pro-apoptotic and anti-apoptotic proteins, thereby activating or inhibiting cancer-promoting and cancer-suppressing pathways (Trotta and Chipuk, 2017). The gene discussed is BCL2; the disease is neoplasm.