Additionally, the expression of pro-apoptotic proteins such as caspase-3, caspase-7, caspase-8, caspase-9, and bax was significantly increased, while the expression of Bcl-2 decreased, which may be related to the activation of the mitochondria-dependent apoptosis pathway and the p53 tumor suppressor pathway. This evidence concerns the gene CASP3 and neoplasm.