The results depicted that RAC1 expression was positively correlated with many immune checkpoints, such as PDCD1, LAG3, CTLA4, HAVCR2, and TIGIT, and immunosuppressive factors, such as CSF1R, IL10, TGFB1, TGFBR1, and VTCN1, in most cancer types, namely ACC, BLCA, BRCA, KICH, KIRC, KIRP, LGG, LIHC, PAAD, PCPG, PRAD, and UVM. The gene discussed is VTCN1; the disease is cancer.