This study identified preoperative oxygenation index (OI), body mass index (BMI), C-reactive protein (CRP), D-dimer levels, moderate hypothermic circulatory arrest (MHCA) time, and cardiopulmonary bypass (CPB) duration as independent risk factors for severe acute lung injury (ALI) following ATAAD surgery. The gene discussed is CRP; the disease is acute respiratory distress syndrome.