In the subgroup of individuals with diabetes onset before the age of 45, GFR was significantly lower in those with the H19 SNP rs3741219 AG+GG genotype compared to those with the AA genotype (72.66 ± 35.19 versus 84.59 ± 34.84, p = 0.012) (Figure 1A). The gene discussed is H19; the disease is diabetes mellitus.