Upon overexpression of OCT4 and VCC-1 in H1299 cells by transfection of pCMV-Tag2B-OCT4 and pCMV-Tag2B-VCC-1, respectively, a notable augmentation in TGF-β production was observed in cancer cells overexpressing OCT4 (Figure 3A) and VCC-1 (Figure 3B) in a dose-dependent manner, as examined by ELISA. The gene discussed is POU5F1; the disease is cancer.