Furthermore, sodium isosteviol has the potential to ameliorate high‐fat/high‐cholesterol‐induced kidney disorders, myocardial dysfunction, and nonalcoholic fatty liver disease (NAFLD) through the activation of the Sirtuin 1 (Sirt1)/AMPK signaling pathway and the suppression of inflammation (Mei et al. 2022a, 2022b, 2020). This evidence concerns the gene SIRT1 and kidney disorder.