The study of hypocaloric sweeteners S. rebaudiana Bertoni and STV on hepatic steatosis and hepatocyte autophagy showed that S and SS increased the levels of fatty acid oxidase, peroxisome proliferator‐activated receptor α (PPAR) and microtubule‐associated protein light chain 3b, and decreased the levels of lock sequestosome 1 (p62) in the liver of db/db mice, and knockout of PPAR blocked STV‐mediated lipid phagocytosis of HepG2 cells (Park, Sharma, et al. 2022). This evidence concerns the gene SQSTM1 and fatty liver disease.