AKT1 and neoplasm: SPP‐ARV‐825 effectively reduced tumor cell proliferation, induced apoptosis, and suppressed M2 macrophage polarization by inhibiting interferon regulatory factor 4 (IRF4) transcription and the phosphorylation of signal transducer and activator of transcription 6 (STAT6), STAT3, and protein kinase B (AKT).