Breast cancer, the leading cause of mortality (Khurram et al. 2023), has a common nuclear receptors, such as ER‐α and ER‐β, control the expression of gene ER‐α is the main controller that causes estrogen transduction in the reproductive tract of females and glands in the breasts and plays a role in a variety of biological mechanisms. Here, ESR1 is linked to breast carcinoma.