In addition to the previously mentioned lncRNAs that have regulatory effects on CAVD, other lncRNAs, such as myocardial infarction-associated transcript (MIAT) and antisense non-coding RNA in the INK4 locus (ANRIL), may regulate osteogenic differentiation and inflammatory responses in various cells, suggesting that they could have similar mechanisms in the aortic valve. Here, CDKN2A is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.