Importantly, VET decreased the time taken to the correct hole in the APP/PS1Tg mice, demonstrating that VET improved cognitive decline in our mouse model of AD (Figure 2E; ANOVA, exercise × genotype interaction, F3,54 = 8.740, p < 0.0001; pairwise comparison: sed WT vs. sed APP p < 0.0001, sed APP vs. ex WT p = 0.0004, sed APP vs. ex APP p = 0.0146). This evidence concerns the gene APP and Alzheimer disease.