GH1 and hyperinsulinemic hypoglycemia, familial, 4: Analyzing the effect of pubertal development in the 23 subjects with GH deficiency treated with GH, we did not observe any significant difference compared to untreated patients regarding the duration of the growth spurt, spurt gain, and FH, confirming the positive effect of GH therapy in those with a deficiency, as previously reported by Tamburrino et al.