For example, research similar to studies demonstrating curcumin's role in alleviating diet-induced spatial memory impairment and hepatic metabolism in Alzheimer's disease-induced (3xTg-AD) mice [58], or its ability to reduce cellular senescence by modulating the MAPK/NF-κB signaling pathway in aged mice [55], could offer valuable insights into the diverse applications of curcumin in promoting healthy aging. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.