IL11RA and neoplasm: This nanocomposite hydrogel is dynamic and responds to the tumor microenvironment of MYC-amplified OS, which consists of free NHWD-870 (NH) and IL11Rα-targeted liposomes containing cisplatin-loaded MnO2 (Cis/Mn@Lipo-IL11), providing powerful targeted therapy and immune modulation against OS progression and metastasis (Fig. 1).