In the animal models, the Cis/Mn/NH@PGP hydrogels underwent in situ gelation upon injection and degrades within the tumor microenvironment over time, continuously releasing NHWD-870 and embedded nanoparticles for cisplatin release, thus inhibiting OS tumor growth and metastasis by degrading MYC and modulating the immune-suppressive TME. This evidence concerns the gene MYC and neoplasm.