Consistent with these considerations, silymarin/silybin decreased the mitochondrial degradation of straight-chain, odd-chain, and branched fatty acids (CPT2, ACAA1, ACAA2, HADH, ACADS, HADHB, PCCA, MCEE, Figure 4B, C, D, E, Figure S11) as well as peroxisomal oxidation (ABCD1, ACOX2, PHYH, Figure 4C and E, Figure S11) and ketogenesis (HMGCS2, BDH1, HMGCLL1, Figure 4B, C, E), especially in mouse liver in vivo and Huh7.5.1 hepatoma cells in vitro. Here, HADH is linked to hepatocellular carcinoma.