Elevated Kla levels were observed in the nuclei of intraductal papillary mucinous neoplasms, non-invasive intraductal papillary mucinous carcinomas, and invasive cancers, along with increased hypoxia-inducible factor-1α levels, suggesting that hypoxia-related nuclear protein Kla could serve as a biochemical marker for pancreatic epithelial tumors 124. Here, KL is linked to pancreatic intraductal papillary-mucinous neoplasm.