Based on the median expression of TBX3 in the TCGA-BLCA cohort, we divided the TCGA-BLCA cohort into high and low TBX3-expressing groups and found that the immune effector genes from CD8+ T cells, natural killer (NK) cells, macrophages, type 1 T helper (Th1) cells, and dendritic cells were all expressed higher in the low TBX3-expressing group (Figure 2D). Here, CD8A is linked to bladder transitional cell carcinoma.