TBX3 and bladder transitional cell carcinoma: To reveal the mechanism underlying TBX3 promoting an immunosuppressive microenvironment, we first performed GO and KEGG enrichment analysis based on the TCGA-BLCA cohort and found that the DEGs between the high and low TBX3 expression groups were mainly enriched on cytokine and extracellular matrix (ECM)-related pathways (Figures 4A-B).