TGFB1 and neoplasm: In addition, the role of GFs goes far beyond promoting angiogenesis, for example, transforming growth factor-β (TGF-β) 72, platelet-derived growth factor (PDGF) 73, fibroblast growth factor (FGF) 74, and other members of the GF family can also activate stromal cells such as fibroblasts, triggering structural remodeling and functional adjustment of tumor stroma.