Within the top five genes based on WRF (Ensemble 1 and Ensemble 2), SLC30A3, MOS, C1ORF61, and MBL1P genes were found to have an association with CRC (Lin et al., 2007; Zheng et al., 2015; Yin et al., 2020; Peng et al., 2021; Cui et al., 2022), gene PAGE2, a gene from cancer-germline genes, was found to be upregulated in Caco-2 colorectal cancer cell line (Yilmaz-Ozcan et al., 2014). This evidence concerns the gene PAGE2 and cancer.