Melanoma cells adapt to immune pressure by modulating the tumor microenvironment, including the upregulation of immune checkpoint molecules such as PD-L1 or by promoting a suppressive microenvironment through the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) (Liu et al., 2020; Liu et al., 2023). Here, CD274 is linked to melanoma.