They had a significantly higher rate of hypertension and higher levels of total cholesterol and BNP and lower levels of eGFR, whereas men had a significantly higher BMI, higher rate of smoking, more often chronic ischemic heart disease (angina pectoris, previous percutaneous coronary intervention [PCI] and coronary artery bypass grafting [CABG]) (Table 1). The gene discussed is NPPB; the disease is angina pectoris.