Studies conducted in homozygous LRRK2 KO mice models reported that there is an age-related increase in renal atrophy and degeneration, abnormal accumulation of α-synuclein and ubiquitinated protein, and disruption in the autophagy-lysosomal pathway, but no neurodegeneration was reported in this respect [28]. The gene discussed is LRRK2; the disease is Renal atrophy.