Immunohistochemical expression of L1CAM highlights the TRAF7 mutation [9] and is a useful adjunct to diagnosis, especially in the differential consideration for both benign and malignant tumors such as lymphangioma [10] and metastatic signet ring carcinoma [11], in cases where intracytoplasmic vacuoles may be apparent. This evidence concerns the gene L1CAM and lymphangioma.