On comparative analysis, female gender (p = 0.006), raised serum bilirubin levels (p = 0.009), alkaline phosphatase (p = 0.034), ALT (p = 0.021), AST (p = 0.034), INR (p ≤ 0.001), decreased TLC (p ≤ 0.001) and PLT (p ≤ 0.001), higher ANA titers (p = 0.001), ASMA positivity (p = 0.005), and raised serum IgG levels (p = 0.043) were significantly associated with the presence of advanced liver fibrosis on histopathology. The gene discussed is BTG3; the disease is Hepatic fibrosis.