In 2011, Salaverria et al. elaborated in great detail the cytogenetics, gene expression profile, tumor biology, and clinical characteristics of large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) as a new entity, affecting mainly children and young adults who were previously diagnosed either as DLBCL, GCB type, or follicular lymphoma (FL), grade 3 [9]. Here, IRF4 is linked to diffuse large B-cell lymphoma.