This study suggested significant difference in the mRNA level of C1QC, C1QB, C4BPA, CR1, C9, C6, C4A, CLU, CD59, SERPING1, C1S, C1R, C3AR1, C3 and C5AR1 among AD patients when compared with healthy people through single cell RNA-seq analysis. The gene discussed is C4BPA; the disease is Alzheimer disease.