The frequency of acquired copy number changes in AKR1A1 (Aldo-Keto reductase family 1 member A1), GPI (glucose-6-phosphate isomerase), and MECP2 (methyl-CpG binding protein 2) genes was lower than that of loss in the population of endometrial cancer patients (Fig. S1C). This evidence concerns the gene AKR1A1 and endometrial cancer.