Especially, the gluten-specific CD4+ T cells are known to express CXCR3, responding to the CXCL9 and CXCL10 that are expressed in the coeliac regions, for which CXCL9 and CXCR are suggested as the therapeutic targets for the coeliac disease [115], [116], [117]. The gene discussed is CD4; the disease is celiac disease.