PFKFB3 and plasma cell myeloma: IL-32γ, generated by myeloma cells, potentiates PFKFB3 reliant glycolysis via protease 3, facilitating the activation of the PFKFB3-JAK1 signaling axis, which promotes macrophage expression of PD-L1 and impedes CD8+T cell function to foster the progression of multiple myeloma41.