In cancer cells, CXCL8 integrates with multiple intracellular signaling, including PI3K/AKT, JAK/STAT, and PLC/PKC pathways, to promote tumor growth, metastasis, angiogenesis and chemoresistance through binding to the cell membrane surface receptor CXCR1/2 8, 38. Here, HSPG2 is linked to neoplasm.