USP5 and nasopharyngeal carcinoma: In summary (Fig. 7E), our present study identifies USP5 as a novel interactor of EphA2, and USP5 binds and stabilizes EphA2 via ubiquitin proteasome pathway in NPC cells, and demonstrates that USP5/EphA2 axis promotes NPC radioresistance, and MBZ has an obvious radiosensitizing effect on NPC by targeting USP5/EphA2 axis.