IHC showed that expression levels of both USP5 and EphA2 in the cancer tissues were significantly higher than those in the normal tissues (Fig. S7), and USP5 levels were positively correlated with EphA2 levels in cancer tissues (Fig. 7A), supporting USP5 as the deubiquitinase of EphA2 in NPC. Here, EPHA2 is linked to nasopharyngeal carcinoma.