Both flow cytometric analysis of cell apoptosis and immunofluorescent staining of γH2AX foci showed that either EphA2 or USP5 overexpression antagonized irradiation-induced cell apoptosis and γH2AX focus formation of NPC cells treated with MBZ (Fig. 6B and C). The gene discussed is USP5; the disease is nasopharyngeal carcinoma.