USP5 and neoplasm: As shown in Figure 6E-G, treatment of the tumor-bearing mice with MBZ or IR significantly inhibited the growth of tumors generated from vector control 5-8F NPC cells, the combination of MBZ with IR treatment had stronger tumor suppression compared with IR alone, and either EphA2 or USP5 overexpression antagonized radiosensitizing effect of MBZ on the xenografted tumors.