EPHA2 and nasopharyngeal carcinoma: To confirm MBZ-downregulated EphA2 expression at the posttranscriptional level, we analyzed the effect of MBZ on EphA2 protein stability after blocking protein synthesis with CHX, and observed that EphA2 was rapidly degraded in the MBZ-treated NPC cells (Fig. 3D), indicating that MBZ decreased EphA2 protein stability.