Among that DLL3 as a member of the Delta/serrated/Lag-2 ligand family, is an inhibitory ligand for tumor-specific surface antigens and the Notch signaling pathway in SCLC cells, encoding for inhibition of the activation of the Notch signaling pathway, thereby affecting tumorigenesis, progression, and/or chemoresistance. Here, DLL3 is linked to small cell lung carcinoma.