The pathological hallmarks of AD include the deposition of amyloid-beta (Aβ) aggregates, commonly known as amyloid plaques, and accumulation of hyperphosphorylated Tau (p-Tau) protein, resulting in neurofibrillary tangles (NFTs), along with widespread neuronal degeneration 1 (Fig. 1). Here, MAPT is linked to Alzheimer disease.