TFEB and Alzheimer disease: This dysfunction is associated with faulty acidification, impaired autophagy, and release of lysosomal hydrolases, and 2) therapeutic strategies focused on improving lysosomal stress, lysosomal repair, replacement, reformation, or lysophagy through pharmacologic agents or genetic measure that activate TFEB or related genes may provide new approaches to retard, halt, or reverse disease progression and to treat AD.