Specifically, HIF-2α expressed by cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) influences tumor fibrosis, and the absence of CAF-HIF2 significantly inhibits the intratumoral recruitment of M2 macrophages and regulatory T cells (Tregs) and modestly reduced tumor fibrosis35. The gene discussed is EPAS1; the disease is neoplasm.