Compared with that in paired normal tissues, FTO was downregulated in breast carcinoma (BRCA), cervical carcinoma (CESC), COAD, lung carcinoma (LUAD and LUSC), and uterine cancer (UCEC and UCS) tissues but upregulated in esophageal carcinoma (ESCA), pancreatic adenocarcinoma (PAAD), and stomach adenocarcinoma (STAD) tissues, according to TCGA pancancer RNA-seq datasets 40-42. The gene discussed is FTO; the disease is invasive breast carcinoma.