TTC7B and malignant colon neoplasm: We further studied the effect of TTC7B on the proliferation of colon cancer cells and found that TTC7B-OE significantly inhibited the proliferation of HCT116, LoVo, and SW480 cells (Figure S11A), whereas TTC7B-KO significantly increased the proliferation and colony formation of HCT116 and SW480 cells (Figure S11B and S11C).