This possibility has also been confirmed by recent studies, such as DNMTis in combination with conventional compounds for the treatment of advanced breast cancer, which improves the therapeutic efficacy262, and in colorectal cancer, where it has been found that the histone demethylase PHF8 can act as an essential mediator of immune evasion and its absence can stimulate a viral mimicry response. This evidence concerns the gene PHF8 and colorectal cancer.