CD274 and colorectal carcinoma: In addition, Yang et al. found that a dual inhibitor (C02S) of DNA methyltransferases and histone deacetylases, not only upregulated ERVs and activated viral mimicry responses through the MDA5-MAVS signaling pathway in colorectal cancer (CRC) model, but also remodeled the tumor immune microenvironment (TME), enhanced immune cell infiltration, and significantly improved the efficacy of anti-PD-L1 therapy in CRC mouse model.