Utilizing dehydroepiandrosterone-induced PCOS rat (Sprague Dawley) model and the ovarian granulosa cell line, KGN, Li and colleagues 136 investigated the effect of the ADMA-dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway on redox status and ovarian apoptosis. This evidence concerns the gene DDAH1 and polycystic ovary syndrome.